In this slideset, Professor Shabir Madhi, WAidid board member, analyses the trends in global and sub-Saharan Africa under-5 childhood mortality. He demonstrates the contribution of new childhood vaccines against major pathogens causing diarrhoea, pneumonia and meningitis in reducing under-5/neonatal morbidity and mortality and concludes presenting the next frontier: targeting vaccination of pregnant women for reducing death from neonatal and early-infancy vaccine-preventable diseases.