The article suggested by WAidid this week, Genome-wide association studies in infectious diseases, has been published on The Pediatric Infectious Disease Journal on May 2016; this is the official publication of ESPID - European Society for Paediatric Infectious Diseases.
One of the most puzzling questions is why some children suffer from severe and life- threatening infections, while others who are exposed to the same pathogen remain uninfected, or suffer only from mild illness. There is now growing evidence that differences in host genetics play a major role in determining susceptibility and outcome of childhood infections, in addition to environmental factors. With subsequent human genetic variant mapping and improvements in technology , it became possible to search of genes influencing humans disease without any prior biological knowledge- a process now know as a genome-wide association study (GWAS). GWAS has emerged as a powerful tool to identify the genes underlying susceptibility and severity of many diseases.
AUTHORS: Seaby, Eleanor G.; Wright, Victoria J.; Levin, Michael
Summer is coming, so this week WAidid suggests an article on diarrhea, that is the most common travel-associated illness. The paper was published last May on Pediatric Infectious Disease Journal.
This paper intends to provide an update on existing knowledge on this topic in children, highlight clinical areas requiring further research and training, and conclude with practical recommendations:
AUTHORS: Ashkenazi S, Schwartz E, O'Ryan M.